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da Vinci 21 Growth Factors (Professional Use)

The da Vinci 21 Growth Factor Protein Serum is an intense anti-aging wrinkle treatment with a non-comedogenic formula with anti-inflammatory properties.

This isn’t just a step forward in cosmetics, it’s revolutionary.

What is da Vinci 21?

da Vinci 21 is a professional grade anti-aging serum containing 5 types of growth factor proteins specifically engineered in Korea for anti-aging and skin rejuvenation. da Vinci 21 contains an incredible 21,000 ng/ml of 5 different growth factors working together to rejuvenate your skin. The high concentration of Growth Factor Proteins is not only the highest in the industry, but it is composed of the purest Growth Factor Proteins in the industry. The unmatched level of purity in our Growth Factor Proteins (>99.9%) leads to better results and makes this the ultimate skin rejuvenation solution.

da Vinci Growth Factors smooth & lessen the appearance of fine lines & wrinkles. Enriched with powerful antioxidants and moisture binding Hyaluronic Acid, da Vinci 21 reinforces the skin's immune function to safeguard future aging. Your skin reveals a softer, brighter, clarified and younger looking complexion.

Growth Factor Proteins included in the da Vinci Complex are bFGF, IFG-1, KGF-2, EGF, and SOD-1. For more detailed information of each of these Growth Factor Proteins and their role in skin care, view the Science section of this website.

Hyaluronic Acid (HA) plays an important role in our formula.

Our HA is a high Molecular weight, polyanionic polysaccharide and is naturally present in virtually all vertebrate tissues and fluids including the skin's extracellular matrix. HA has a strong and complex relationship with the skin both physicochemically and biologically. HA supports the skin's architecture. It governs the skin's elasticity, it is involved in migration and differentiation processes during wound healing and inflammation. We use HA in our formula for the following reasons:

  • Assist the delivery of the growth factors to the dermis for an effective treatment
  • Support the skin's architecture and elasticity
  • Encourage wound healing
  • Provide anti-inflammatory support to the skin 

Growth Factor Protein Stability

There are a variety of cosmetic products on the market containing Growth Factor Proteins. None of them are as efficacious or as powerful as ours. Often when you purchase an anti-aging cream containing growth factors, the growth factors within the bottle are not very stable. This means, the Proteins begin to break down while present mixed in the cream or serum. By the time the product comes in contact with your skin, the Growth Factor Proteins have been broken down by the cream or serum and are not effective.

Architects of Skin understand the complex, scientific nature of Growth Factors and respect the product's stability. As such, we have designed a unique bottle containing two chambers. One for the HA serum and one for the growth factor protein powder. By keeping the two ingredients separate, we can guarantee 99.9% activity of our growth factors on your skin. 

How is the product applied?

da Vinci 21 requires micro-needling prior to application to ensure the large, powerful protein molecules penetrate into the lower layers of dermis. da Vinci 21 is also affective when applied after fractional laser treatment and laser resurfacing treatment. For more information on these procedures, please contact Architects of Skin or speak with a skin care professional.

To open the bottle and activate the Growth Factor Protein Complex, push the pump down on the top of the bottle to crack the seal isolating the Complex and gently rotate the bottle to mix the complex into the serum.

The standard treatment procedure recommended in conjunction with micro-needling is:

  • Micro-needle the target area and apply da Vinci 21 once per week for 8-10 weeks. The amount of time can vary based on the starting point of the patient. This weekly “ramp up” period is required to consistently increase the levels of active Growth Factor Proteins in the dermis. “Ramp up” treatments can be performed every other week instead of weekly, but the results will not be perceived as quickly.
  • After each micro needling session, pump a drop of the serum into the hand and then rub the serum into the skin. The number of drops used depends on the size of the target area of skin.
  • Once the “ramp up” period is completed, repeat the process monthly to maintain results.
  • Between treatments, apply da Vinci 10 for Home Use on a daily basis. 


When applying da Vinci 21 specifically to the face, one bottle generally can be used for 10+ applications. This will vary based upon the size of target surface area.


Once opened, it is recommended to refrigerate your da Vinci 10 bottle to best preserve its effectiveness. Warmer environments (Above 15°C/59°F) accelerate the natural degradation of Growth Factor Proteins that begins when the Growth Factor Complex (White Powder in the bottle) is mixed with the liquid serum. When refrigerated, the Growth Factor Proteins in the Complex remain at least 98% active for one month and at least 90% active for two months.

For Medical and Skin Care Professionals

The science behind da Vinci 21s Growth Factor Protein Complex is widely recognized and proven. This is illustrated with over 20 patents on this specific technology and multiple articles published in leading professional dermatology medical journals.

Growth Factor Protein technology has been used for years in the treatment of anemia in people with chronic kidney disease and to accelerate recovery from neutropenia in cancer patients after chemotherapy. The high cost to producing quality Growth Factor Proteins has previously been limited the applications of Growth Factor Protein technology. Architects of Skin leverages unique technology founded with over 20 patents to produce natural Growth Factor Proteins with a purity and cost that now makes them available for cosmetic uses.

Prior attempts by other companies have resulted in Growth Factor Proteins with low purity (<50%). The inactive Growth Factors in these complexes can cause more harm than the good caused by the active growth factors due to the body’s immune response to unrecognized proteins in the skin. Growth Factor Proteins from Architects of Skin have greater than 99.9% purity. These results are not only ground-breaking for the cosmetic market, but they provide a whole new option for dermatologists and patients looking for new technology that works.

For more detailed information of each of these Growth Factor Proteins and their role in skin care, view the Science section of this website.

da Vinci 21 Growth Factors for Skin Rejuvenation:

  • Professional Use
  • 21,000ng/ml
  • 1x 15ml

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